Interactive structural biology · Open data

NKG2D recognition complex — 3D молекулярный viewer

Интерактивная 3D структура human NKG2D extracellular domain bound к MICA — published crystallographic basis для recognition module of NKG2D-LIF6 chimera. Rotate, zoom, switch representations в любом modern browser. WebXR-capable browsers (Quest, Vision Pro Safari, AR-capable mobile Chrome) могут запускать viewer в AR/VR через кнопку ниже.

Reference structure: PDB 1HYR — Crystal structure human NKG2D-MICA complex (Li et al. 2001, Nature Immunology)
Source: RCSB Protein Data Bank (CC0 public domain, NCBI)
Resolution: 2.7 Å
Components shown: NKG2D extracellular domain (chain A) · MICA α1+α2 platform (chain B)
Relevance к Nightbox: NKG2D extracellular domain shown (residues 79-216) — recognition module of NKG2D-LIF6 chimera (NBX-001). MICA ligand shown — tumor-restricted stress signal на который chimera отвечает.

Чтение структуры

NKG2D ECD (chain A): C-type lectin-like fold что recognizes MICA. Это residue range (79-216) используемый в chimeric construct.
MICA (chain B): stress-induced ligand expressed selectively на transformed и stressed cells — tumor-restricted signal на который chimera отвечает.
Interface: NKG2D engages MICA's α1-α2 platform через specific contact surface. Published crystallographic interface guides chimera's selectivity argument.

Что NOT shown здесь

Chimera fusion construct сам — published crystal structure пока в работе (in silico design only)
Elephant LIF6 effector domain — модельирован AlphaFold3; full 3D rendering будет released alongside wet-lab validation data Q3-Q4 2026
Mitochondrial localization context

Open methodology

Structural validation pipeline (AlphaFold3 + RoseTTAFold all-atom + PyMOL + Rosetta refinement) для NKG2D-LIF6 chimera задокументирован на github.com/nightbox-llc/chimera-design-notes/METHODS.md под CC BY 4.0.

Использование viewer в своей работе

Viewer open-source — pulls PDB files напрямую с RCSB CDN, uses NGL viewer JS library (MIT license), и полностью embeddable. Right-click → "Inspect" чтобы увидеть implementation. Или fork на github.com/nightbox-llc/nightbox-website.

PDB structures shown — public domain (CC0) по RCSB Protein Data Bank policy. Molecular visualization powered by NGL Viewer (MIT license, Rose et al. 2018).