Часто задаваемые

2,123 bp chimeric receptor-effector gene therapy construct, fusing human NKG2D ectodomain с elephant LIF6 mitochondrial apoptosis effector. Single AAV9 payload, без autologous cell processing.

LIF6 — re-functionalized pseudogene, driving elephant cancer-resistance phenotype, который explains Peto's Paradox (Vazquez et al. 2018, Cell Reports). Single-purpose mitochondrial puncher с cleaner pharmacology, чем upstream sensors типа TP53.

Иной подход. CAR-T requires extracting и engineering patient's own T cells, потом reinfusing — significant manufacturing complexity. NKG2D-LIF6 — single-construct gene therapy, delivered как one AAV9 payload, без autologous cell processing.

Чистая IP whitespace на specific NKG2D-LIF6 chimera. Provisional patent в работе. Comprehensive freedom-to-operate analysis complete; zero prior art identified на combination.

Pre-seed. In silico validation complete (~99% TGI ceiling на CRC syngeneic models). In vivo validation в трёх syngeneic murine tumor models planned для Q2-Q3 2026. Pre-IND meeting target H2 2026. First-in-human Phase 1 target 2027.

Wyoming LLC, EIN 39-4373044, SAM.gov Active с 2026-05-18, CAGE Code 20BA7. Solo founder + production AI agent stack. Convert в Delaware C-corp at Series A или earlier, если required lead investor.

Отправь brief note на investors@nightboxllc.com (firm, focus areas, ticket size, lead-vs-follow). Share data-room access в течение 24 часов и schedule working call. Round и use-of-proceeds detail на /ru/investors.

Да. Real Claude через Vercel AI Gateway с full Nightbox context. Может answer technical questions про NKG2D-LIF6 и Liaison Framework directly. Site infrastructure: Vercel Edge runtime, streaming SSE, prompt-injection defense, output sanitization.

Email partnerships@nightboxllc.com с one-paragraph fit hypothesis. Отвечаем на каждое well-targeted письмо.

press@nightboxllc.com · factsheet на /ru/press

NIGHTBOX операционная доктрина по двустороннему сотрудничеству США ↔ Россия. Россия — partner state. Anti-state-capture симметрично. Transparent business-liaison architecture по модели US FARA + LDA + EU Transparency Register. Полная доктрина: /ru/liaison-framework