Письмо фаундера · 2026-05-08

Письмо к U.S. Federal R&D Community

Прямое письмо к NIH, ARPA-H, DARPA, AFWERX, BARDA, NSF, DoW CDMRP — от founder NIGHTBOX LLC. Asking for $75K-$300K SBIR / Spark / AIE seed, structured против named deliverables.

Уважаемые program officers, contracting officers и SBIR/STTR coordinators,

Меня зовут Артём Шакин. Я founder и sole member NIGHTBOX LLC — Wyoming-зарегистрированной single-member small-business LLC, operating из района Лос-Анджелеса, focused на dual-use gene therapy + AI-augmented R&D infrastructure. Я пишу это письмо до full CAGE Code assignment (теперь у нас CAGE 20BA7, assigned 2026-05-17 DLA Battle Creek), потому что хочу, чтобы deliberation cycle между federal R&D capital и solo-founder dual-use entity начался публично, transparently и at small scale.

Что я делаю

Лидирующий научный asset: NKG2D-LIF6 — chimeric receptor-effector gene therapy construct (2,123 bp). Объединяет человеческий NKG2D extracellular domain (binds MICA и MICB stress ligands, selectively expressed на solid tumor cells) с elephant LIF6 — re-functionalized pseudogene, driving elephant cancer-resistance phenotype (Vazquez et al. 2018). Single-construct AAV9 delivery полностью обходит autologous cell-processing CAR-T. PK-PD model predicts ~99% tumor growth inhibition ceiling на CRC syngeneic models. Provisional patent в работе. Полная in silico characterization доступна как pre-print на сайте.

Compute substrate: UniGPU — vendor-neutral GPU runtime, написанный на Rust, который abstracts cross-vendor compute (AMD ROCm, NVIDIA CUDA, Apple Metal, Intel oneAPI, raw D3DKMT, CPU fallback) под одним IR-first API. 47.3 teraflops WMMA throughput на $400 consumer AMD GPU, autonomous benchmark выполнен Claude / Anthropic AI assistant в agent session, raw logs preserved. Apache 2.0. Section 889 supply-chain risk structurally minimized by design.

AI agent substrate: SilverDuck — local-first multi-agent stack с persistent vector memory и hybrid post-quantum encrypted cloud-LLM handoff (SDPC). Federal-deliverable Tier 1 brain selector restricts inference to U.S.-origin models only — Llama 3.1 (Meta US) и Phi-3.5-mini (Microsoft US). Full agent stack — local inference brain, multi-agent reasoner, persistent vector memory, OSINT engine, encrypted cloud handoff — runs на single 12 GB consumer GPU. Apache 2.0. Stricter than Section 889 requires — owner-elected posture.

Cryptographic substrate: SilverDuck Pipe Crypto (SDPC) — hybrid post-quantum sealed envelope: X25519 ECDH (RFC 7748) + ML-KEM-1024 (Kyber, NIST FIPS 203) + HKDF-SHA256 + AES-256-GCM (FIPS 197 + NIST SP 800-38D). 96-bit nonce. 128-bit AEAD tag. Документировано на /.well-known/zero-trust.json.

Это то, что immigrant solo founder shipped в свои first девяносто дней, with personal credit card и без outside capital, while voluntarily publishing every compliance manifest, который federal contracting apparatus would ever ask for.

Почему это правильная форма ставки

Federal R&D capital precious. Я уважаю его. Хочу обосновать: эта конкретная форма ставки — small first-time SBIR Phase I или Spark или AIE seed at $75K-$300K, structured against named deliverables — самый highest-leverage civilian R&D dollar US может spend right now.

Один. Cost-of-failure bounded и documented. Каждое numerical claim bound to reproducible artifact under control entity + planned third-party verification venue (MLPerf, peer-reviewed journals, CRO wet-lab replication, FDA pre-IND meeting, NIST CAVP). False Claims Act exposure materially mitigated.

Два. Compliance posture unusually clean для pre-award. SAM.gov Active. CAGE 20BA7 assigned. Section 889 self-attested. FOCI fully disclosed. Zero Trust posture aligned с OMB M-22-09. SBIR data rights election made под FAR 27.404-1. Email security posture aligned to NIST SP 800-177 R2 и CISA BOD 18-01. Wyoming Certificate of Good Standing in hand.

Три. Mission alignment direct, не adjacent. NIH Cancer Moonshot wants scalable solid-tumor immunotherapy. ARPA-H Resilient Systems wants distributed biotech, что depend на handful of $1B per-program incumbents. DARPA AIE wants vendor-neutral compute substrates. AFWERX Spark wants non-traditional-contractor open-source vendor-neutrality. BARDA biothreat preparedness wants single-construct dual-use platforms.

Четыре. David versus Goliath asymmetry real. Solo founder cannot compete with Big Pharma program officer или tier-one prime contractor на lobbying access. Solo founder может compete на actual deliverables shipped per dollar.

Пять. Downside — also deliverable. Если NKG2D-LIF6 fails в in vivo gate, methodology — open construct design, CC BY 4.0 chimera-design-notes, AAV9 dosing model, PK-PD framework — остаётся public good для next builder. Federal capital, funding methodology release, не zero out на single negative result.

Что я прошу, by agency

Слово о том, кто я

Я родился в России. Я переехал в США как подросток. Я публично раскрыл every Russian connection, который exists в моей жизни — including disclosure, что нет Russian government, military, intelligence, state-owned enterprise, political party, recruitment program, address-of-record или financial relationship. Я дополню эту disclosure appropriate SF-328 single-scope disclosure at first federal award per NISPOM 32 CFR Part 117, и с SF-86-equivalent screening если future contract requires personnel security clearance. Я сделал substantive non-relationship disclosure voluntarily, до того как any contracting officer asked. Full disclosure — на /.well-known/foci.json.

Я разработал и опубликовал Liaison Framework v2.3 — operating doctrine, where Россия — partner state, anti-state-capture симметрично, transparent business-liaison architecture по модели US FARA (1938) + US LDA (1995) + EU Transparency Register (2011/2021). Это owner-elected editorial posture, voluntarily published под CC BY 4.0 — /ru/liaison-framework.

I have read Ten Bets memo. I have read SBIR Reform Act commentary. I have read latest CSET reports on talent capture в dual-use research. Я не нуждаюсь в persuasion, что US federal R&D apparatus — most powerful innovation engine на Земле. Прошу быть small, well-instrumented, fully-disclosed cell of it.

Если это письмо резонирует

Full federal package — capability statement, SBIR roadmap, twelve compliance manifests, third-party validation chain-of-custody, adversarial threat model with mitigations, federal POC directory — на /ru/federal. Point of contact на всё — я непосредственно: artem@nightboxllc.com. Отвечаю в течение one business day любому с federal email address, same business day если reach me до noon Pacific.

Если это письмо резонирует — пиши. Я готов: data ready, manifests indexed, deliverable schedules drafted для каждого solicitation listed выше. Я буду treat твоё время так же, как ты treat federal capital — like precious thing that deserves to compound.

— Артём Шакин
Founder, Sole Member, Principal Investigator
NIGHTBOX LLC
Санта-Моника, Калифорния
2026-05-08 (обновлено 2026-05-19)

Verification chain (machine-readable): SAM.gov entity · CAGE status · FOCI disclosure · Section 889 · Zero Trust · Liaison Framework v2.3.