Глоссарий

Adeno-associated virus, serotype 9. Non-pathogenic gene therapy delivery vector с broad tissue tropism, crosses blood-brain barrier. FDA-approved (Zolgensma для SMA). Подробнее: /ru/science/aav9.

Chimeric Antigen Receptor T-cell therapy. Autologous cell processing: extract patient's T-cells, engineer, reinfuse. High manufacturing complexity. FDA-approved для blood cancers (Kymriah, Yescarta).

Genetic construct, fusing two или more functional protein domains. В нашем случае: NKG2D recognition + LIF6 effector в single 2,123 bp construct.

Investigational New Drug application — FDA filing, который allows human clinical trials. Pre-IND meeting — informal FDA consultation до formal submission.

Leukemia Inhibitory Factor 6 — elephant pseudogene, который dead 59M лет и был re-functionalized как mitochondrial apoptosis kill switch. Drives elephant cancer resistance. Подробнее: /ru/science/lif6.

MHC Class I Polypeptide-Related Sequence A/B. Stress ligands, selectively upregulated на tumor cells и stressed cells. Recognized NKG2D receptor.

Natural-Killer Group 2 Member D. Activating receptor на NK cells, γδ T cells и CD8+ T cells. Binds MICA/MICB stress ligands. Подробнее: /ru/science/nkg2d.

Observation, что у large/long-lived animals (elephants, whales) cancer rates пропорциональны body cell count. Эволюция решила задачу cancer resistance multiple times. Подробнее: /ru/science/peto-paradox.

Mouse model, где tumor cells implanted в genetically identical immunocompetent host. Preserves immune system context для immunotherapy testing.

Tumor Growth Inhibition — percentage reduction в tumor volume или mass relative to vehicle control. Standard preclinical efficacy metric.

Master tumor suppressor gene. У humans 1 functional copy; у elephants ~20 copies (TP53 retrogene expansion).

Commercial and Government Entity Code — 5-character alphanumeric identifier, assigned DLA. NIGHTBOX CAGE: 20BA7 (assigned 2026-05-17 by DLA Battle Creek).

Cybersecurity Maturity Model Certification — DoD framework для contractor cybersecurity. Level 1 (basic) — Level 3 (advanced). NIGHTBOX self-attested L1.

Foreign Ownership, Control or Influence — security review для federal contractors с foreign connections. NIGHTBOX FOCI disclosure: .well-known/foci.json.

Foreign Agents Registration Act (22 U.S.C. § 611). Registration of persons acting as agents of foreign principals. NIGHTBOX outside scope.

Lobbying Disclosure Act (2 U.S.C. § 1601). Registration paid lobbyists. NIGHTBOX outside scope.

North American Industry Classification System. NIGHTBOX primary NAICS: 541714 (R&D в Biotechnology, except Nanobiotechnology).

Office of Foreign Assets Control (Treasury). Administers economic sanctions, including Russia-related (31 C.F.R. Part 587). NIGHTBOX fully compliant.

System for Award Management — federal contracting database. NIGHTBOX UEI: UHCAB6UXXKF2, Active с 2026-05-18.

Small Business Innovation Research / Technology Transfer programs. Federal small-business R&D funding. Phase I ($75-400K), Phase II ($1-2M), Phase III (commercialization).

NDAA 2019 § 889 — ban на covered Huawei/ZTE/Hytera/Hikvision/Dahua telecommunications equipment в federal contracts. NIGHTBOX fully compliant.

Unique Entity Identifier — 12-character SAM.gov identifier, replaced DUNS в 2022. NIGHTBOX UEI: UHCAB6UXXKF2.

NIGHTBOX operating doctrine по двустороннему сотрудничеству США ↔ Россия. Russia as partner state, anti-state-capture симметрично. Подробнее: /ru/liaison-framework.

Commerce companion к Liaison Framework. Документирует 14+ западных компаний maintaining IP в Rospatent through 2025 + 3-фазная модель возврата. Подробнее: /ru/market-reentry-roadmap.

Ecosystem-development стратегия NIGHTBOX: federal corporate shell + single-steward open-source core. Подробнее: /ru/manifesto.

Vendor-neutral GPU runtime, написанный на Rust. Cross-vendor compute abstraction (AMD ROCm, NVIDIA CUDA, Apple Metal, Intel oneAPI, D3DKMT, CPU). 47.3 TFLOP/s WMMA на consumer AMD GPU.

Local-first AI agent stack с persistent vector memory. Hybrid post-quantum encrypted cloud-LLM handoff (SDPC). Apache 2.0.

Public-facing chat-persona на сайте, powered by Claude через Vercel AI Gateway. Отвечает на технические вопросы про NKG2D-LIF6, Liaison Framework, federal pipeline.